Symbol: Name: ID: |
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 GFS:1735 |
Gene name: | TNFRSF8 |
Chromosome: | 1p36 |
Previous Symbols: | CD30, D1S166E |
Previous Names: | |
Aliases: | KI-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99908 | Rat Genome Database ID: | RGD:3879 |
HGNC ID: | HGNC:11923 | RefSeq IDs: | NM_001243 |
Entrez Gene ID: | 943 | Ensembl Gene ID: | ENSG00000120949 |
VEGA IDs: | OTTHUMG00000001827 | UniProt ID: | P28908 |
UCSC ID: | uc001atq.2 | OMIM ID: | 153243 |
Pubmed: | PMID1330892 PMID 1310894 | ||
CCDS IDs: | CCDSCCDS144.1 CCDS CCDS44057.1 |
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq].
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Products for TNFRSF8 gene
Catalog | Product Name | Application | Company |
GFS:E01735 | tumor necrosis factor receptor superfamily, member 8; ELISA kit | ELISA | n/a |
GFS:A01735 | tumor necrosis factor receptor superfamily, member 8; Anti | ANTIBODIES | n/a |
GFS:P01735 | tumor necrosis factor receptor superfamily, member 8; Protien | Protien | n/a |