Symbol: Name: ID: |
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator GFS:1719 |
Gene name: | TNFRSF11A |
Chromosome: | 18q22.1 |
Previous Symbols: | |
Previous Names: | tumor necrosis factor receptor superfamily, member 11a, activator of NFKB |
Aliases: | RANK, CD265 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1314891 | Rat Genome Database ID: | RGD:1563614 |
HGNC ID: | HGNC:11908 | RefSeq IDs: | NM_003839 |
Entrez Gene ID: | 8792 | Ensembl Gene ID: | ENSG00000141655 |
VEGA IDs: | OTTHUMG00000132779 | UniProt ID: | Q9Y6Q6 |
UCSC ID: | uc002lin.2 | OMIM ID: | 603499 |
Pubmed: | PMID9367155 | ||
CCDS IDs: | CCDSCCDS11980.1 |
Receptor Activator of Nuclear Factor κ B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling.
RANKL (Receptor Activator for Nuclear Factor κ B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
Products for TNFRSF11A gene
Catalog | Product Name | Application | Company |
GFS:E01719 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator; ELISA kit | ELISA | n/a |
GFS:A01719 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator; Anti | ANTIBODIES | n/a |
GFS:P01719 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator; Protien | Protien | n/a |