Symbol: Name: ID: |
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A GFS:1727 |
Gene name: | TNFRSF1A |
Chromosome: | 12p13.2 |
Previous Symbols: | TNFR1 |
Previous Names: | |
Aliases: | TNF-R, TNFAR, TNFR60, TNF-R-I, CD120a, TNF-R55 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1314884 | Rat Genome Database ID: | RGD:621237 |
HGNC ID: | HGNC:11916 | RefSeq IDs: | NM_001065 |
Entrez Gene ID: | 7132 | Ensembl Gene ID: | ENSG00000067182 |
VEGA IDs: | UniProt ID: | P19438 | |
UCSC ID: | uc001qnu.2 | OMIM ID: | 191190 |
Pubmed: | PMID1655358 PMID 2158863 | ||
CCDS IDs: | CCDSCCDS8542.1 |
Tumor necrosis factor receptor superfamily member 1A is a protein that in humans is encoded by the TNFRSF1A gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Products for TNFRSF1A gene
Catalog | Product Name | Application | Company |
GFS:E01727 | tumor necrosis factor receptor superfamily, member 1A; ELISA kit | ELISA | n/a |
GFS:A01727 | tumor necrosis factor receptor superfamily, member 1A; Anti | ANTIBODIES | n/a |
GFS:P01727 | tumor necrosis factor receptor superfamily, member 1A; Protien | Protien | n/a |