Symbol: Name: ID: |
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B GFS:1728 |
Gene name: | TNFRSF1B |
Chromosome: | 1p36.22 |
Previous Symbols: | TNFR2 |
Previous Names: | |
Aliases: | TNFBR, TNFR80, TNF-R75, TNF-R-II, p75, CD120b |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1314883 | Rat Genome Database ID: | RGD:621238 |
HGNC ID: | HGNC:11917 | RefSeq IDs: | NM_001066 |
Entrez Gene ID: | 7133 | Ensembl Gene ID: | ENSG00000028137 |
VEGA IDs: | OTTHUMG00000001829 | UniProt ID: | P20333 |
UCSC ID: | uc001att.2 | OMIM ID: | 191191 |
Pubmed: | PMID2158863 PMID 8702885 | ||
CCDS IDs: | CCDSCCDS145.1 |
Tumor necrosis factor receptor superfamily member 1B is a protein that in humans is encoded by the TNFRSF1B gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Products for TNFRSF1B gene
Catalog | Product Name | Application | Company |
GFS:E01728 | tumor necrosis factor receptor superfamily, member 1B; ELISA kit | ELISA | n/a |
GFS:A01728 | tumor necrosis factor receptor superfamily, member 1B; Anti | ANTIBODIES | n/a |
GFS:P01728 | tumor necrosis factor receptor superfamily, member 1B; Protien | Protien | n/a |