Symbol: Name: ID: |
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C GFS:6670 |
Gene name: | TNFRSF13C |
Chromosome: | 22q13.1-q13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | BAFFR, CD268 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1919299 | Rat Genome Database ID: | RGD:1560810 |
HGNC ID: | HGNC:17755 | RefSeq IDs: | NM_052945 |
Entrez Gene ID: | 115650 | Ensembl Gene ID: | ENSG00000159958 |
VEGA IDs: | OTTHUMG00000151271 | UniProt ID: | Q96RJ3 |
UCSC ID: | uc003bbl.2 | OMIM ID: | 606269 |
Pubmed: | PMID11509692 | ||
CCDS IDs: | CCDSCCDS14024.1 |
Tumor necrosis factor receptor superfamily member 13C is a protein that in humans is encoded by the TNFRSF13C gene.
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Products for TNFRSF13C gene
Catalog | Product Name | Application | Company |
GFS:E06670 | tumor necrosis factor receptor superfamily, member 13C; ELISA kit | ELISA | n/a |
GFS:A06670 | tumor necrosis factor receptor superfamily, member 13C; Anti | ANTIBODIES | n/a |
GFS:P06670 | tumor necrosis factor receptor superfamily, member 13C; Protien | Protien | n/a |