Symbol: Name: ID: |
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a GFS:1715 |
Gene name: | TNFRSF10A |
Chromosome: | 8p21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | DR4, Apo2, TRAILR-1, CD261 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:11904 | RefSeq IDs: | NM_003844 |
Entrez Gene ID: | 8797 | Ensembl Gene ID: | ENSG00000104689 |
VEGA IDs: | OTTHUMG00000097843 | UniProt ID: | O00220 |
UCSC ID: | uc003xda.2 | OMIM ID: | 603611 |
Pubmed: | PMID9311998 PMID 9082980 | ||
CCDS IDs: | CCDSCCDS6039.1 |
Tumor necrosis factor receptor superfamily member 10A is a protein that in humans is encoded by the TNFRSF10A gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Products for TNFRSF10A gene
Catalog | Product Name | Application | Company |
GFS:E01715 | tumor necrosis factor receptor superfamily, member 10a; ELISA kit | ELISA | n/a |
GFS:A01715 | tumor necrosis factor receptor superfamily, member 10a; Anti | ANTIBODIES | n/a |
GFS:P01715 | tumor necrosis factor receptor superfamily, member 10a; Protien | Protien | n/a |