Symbol: Name: ID: |
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 GFS:3038 |
Gene name: | TNFRSF21 |
Chromosome: | 6p21.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | DR6 |
Name Aliases: | death receptor 6 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2151075 | Rat Genome Database ID: | RGD:1307308 |
HGNC ID: | HGNC:13469 | RefSeq IDs: | NM_014452 |
Entrez Gene ID: | 27242 | Ensembl Gene ID: | ENSG00000146072 |
VEGA IDs: | OTTHUMG00000014796 | UniProt ID: | O75509 |
UCSC ID: | uc003oyv.2 | OMIM ID: | 605732 |
Pubmed: | PMID9714541 | ||
CCDS IDs: | CCDSCCDS4921.1 |
Tumor necrosis factor receptor superfamily, member 21, also known as TNFRSF21, is a protein which in humans is encoded by the TNFRSF21 gene.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Products for TNFRSF21 gene
Catalog | Product Name | Application | Company |
GFS:E03038 | tumor necrosis factor receptor superfamily, member 21; ELISA kit | ELISA | n/a |
GFS:A03038 | tumor necrosis factor receptor superfamily, member 21; Anti | ANTIBODIES | n/a |
GFS:P03038 | tumor necrosis factor receptor superfamily, member 21; Protien | Protien | n/a |