Symbol: Name: ID: |
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 GFS:1722 |
Gene name: | TNFRSF25 |
Chromosome: | 1p36.2 |
Previous Symbols: | TNFRSF12 |
Previous Names: | tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein) |
Aliases: | DR3, TRAMP, WSL-1, LARD, WSL-LR, DDR3, TR3, APO-3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1934667 | Rat Genome Database ID: | RGD:1598206 |
HGNC ID: | HGNC:11910 | RefSeq IDs: | NM_001039664 |
Entrez Gene ID: | 8718 | Ensembl Gene ID: | ENSG00000215788 |
VEGA IDs: | OTTHUMG00000000831 | UniProt ID: | Q93038 |
UCSC ID: | uc001ane.2 | OMIM ID: | 603366 |
Pubmed: | PMID9052839 PMID 8934525 | ||
CCDS IDs: | CCDSCCDS71.1 CCDS CCDS72.1 CCDS CCDS73.1 CCDS CCDS74.1 CCDS CCDS75.1 |
Tumor necrosis factor receptor superfamily member 25 is a protein that in humans is encoded by the TNFRSF25 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq].
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Products for TNFRSF25 gene
Catalog | Product Name | Application | Company |
GFS:E01722 | tumor necrosis factor receptor superfamily, member 25; ELISA kit | ELISA | n/a |
GFS:A01722 | tumor necrosis factor receptor superfamily, member 25; Anti | ANTIBODIES | n/a |
GFS:P01722 | tumor necrosis factor receptor superfamily, member 25; Protien | Protien | n/a |