Symbol: Name: ID: |
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 GFS:1725 |
Gene name: | TNFRSF18 |
Chromosome: | 1p36.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | AITR, GITR |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:894675 | Rat Genome Database ID: | RGD:1565872 |
HGNC ID: | HGNC:11914 | RefSeq IDs: | NM_004195 |
Entrez Gene ID: | 8784 | Ensembl Gene ID: | ENSG00000186891 |
VEGA IDs: | OTTHUMG00000001414 | UniProt ID: | Q9Y5U5 |
UCSC ID: | uc001adc.2 | OMIM ID: | 603905 |
Pubmed: | PMID9177197 PMID 10037686 | ||
CCDS IDs: | CCDSCCDS9.1 CCDS CCDS10.1 CCDS CCDS30552.1 |
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18) also known as activation-inducible TNFR family receptor (AITR) or glucocorticoid-induced TNFR-related protein (GITR) is a protein that in humans is encoded by the TNFRSF18 gene. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq].
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Products for TNFRSF18 gene
Catalog | Product Name | Application | Company |
GFS:E01725 | tumor necrosis factor receptor superfamily, member 18; ELISA kit | ELISA | n/a |
GFS:A01725 | tumor necrosis factor receptor superfamily, member 18; Anti | ANTIBODIES | n/a |
GFS:P01725 | tumor necrosis factor receptor superfamily, member 18; Protien | Protien | n/a |