Symbol: Name: ID: |
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B GFS:7039 |
Gene name: | TNFRSF13B |
Chromosome: | 17p11.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TACI, CD267 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1889411 | Rat Genome Database ID: | RGD:1595998 |
HGNC ID: | HGNC:18153 | RefSeq IDs: | NM_012452 |
Entrez Gene ID: | 23495 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000059262 | UniProt ID: | O14836 |
UCSC ID: | uc002gqs.1 | OMIM ID: | 604907 |
Pubmed: | PMID9311921 | ||
CCDS IDs: | CCDSCCDS11181.1 |
Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI, is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system.
The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
Products for TNFRSF13B gene
Catalog | Product Name | Application | Company |
GFS:E07039 | tumor necrosis factor receptor superfamily, member 13B; ELISA kit | ELISA | n/a |
GFS:A07039 | tumor necrosis factor receptor superfamily, member 13B; Anti | ANTIBODIES | n/a |
GFS:P07039 | tumor necrosis factor receptor superfamily, member 13B; Protien | Protien | n/a |