Symbol: Name: ID: |
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) GFS:2286 |
Gene name: | UBE2N |
Chromosome: | 12q22 |
Previous Symbols: | |
Previous Names: | ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13) |
Aliases: | UbcH-ben, UBC13, MGC8489 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1934835 | Rat Genome Database ID: | RGD:621096 |
HGNC ID: | HGNC:12492 | RefSeq IDs: | NM_003348 |
Entrez Gene ID: | 7334 | Ensembl Gene ID: | ENSG00000177889 |
VEGA IDs: | UniProt ID: | P61088 | |
UCSC ID: | uc001tcp.2 | OMIM ID: | 603679 |
Pubmed: | PMID8902611 | ||
CCDS IDs: | CCDSCCDS31875.1 |
Ubiquitin-conjugating enzyme E2 N is a protein that in humans is encoded by the UBE2N gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD.
Products for UBE2N gene
Catalog | Product Name | Application | Company |
GFS:E02286 | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); ELISA kit | ELISA | n/a |
GFS:A02286 | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); Anti | ANTIBODIES | n/a |
GFS:P02286 | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); Protien | Protien | n/a |