Symbol: Name: ID: |
UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog) GFS:2266 |
Gene name: | UBE2B |
Chromosome: | 5q31.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | UBC2, HHR6B |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:102944 | Rat Genome Database ID: | RGD:708345 |
HGNC ID: | HGNC:12473 | RefSeq IDs: | NM_003337 |
Entrez Gene ID: | 7320 | Ensembl Gene ID: | ENSG00000119048 |
VEGA IDs: | OTTHUMG00000129120 | UniProt ID: | P63146 |
UCSC ID: | uc003kzh.2 | OMIM ID: | 179095 |
Pubmed: | PMID1559696 | ||
CCDS IDs: | CCDSCCDS4174.1 |
Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
Products for UBE2B gene
Catalog | Product Name | Application | Company |
GFS:E02266 | ubiquitin-conjugating enzyme E2B (RAD6 homolog); ELISA kit | ELISA | n/a |
GFS:A02266 | ubiquitin-conjugating enzyme E2B (RAD6 homolog); Anti | ANTIBODIES | n/a |
GFS:P02266 | ubiquitin-conjugating enzyme E2B (RAD6 homolog); Protien | Protien | n/a |