Symbol: Name: ID: |
UBE2E3 ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast) GFS:2272 |
Gene name: | UBE2E3 |
Chromosome: | 2q31.3 |
Previous Symbols: | |
Previous Names: | ubiquitin-conjugating enzyme E2E 3 (homologous to yeast UBC4/5) |
Aliases: | UbcH9 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107412 | Rat Genome Database ID: | RGD:1308894 |
HGNC ID: | HGNC:12479 | RefSeq IDs: | NM_006357 |
Entrez Gene ID: | 10477 | Ensembl Gene ID: | ENSG00000170035 |
VEGA IDs: | OTTHUMG00000132585 | UniProt ID: | Q969T4 |
UCSC ID: | uc002unq.1 | OMIM ID: | 604151 |
Pubmed: | PMID10343118 | ||
CCDS IDs: | CCDSCCDS2282.1 |
Ubiquitin-conjugating enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3 gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.
Products for UBE2E3 gene
Catalog | Product Name | Application | Company |
GFS:E02272 | ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast); ELISA kit | ELISA | n/a |
GFS:A02272 | ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast); Anti | ANTIBODIES | n/a |
GFS:P02272 | ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast); Protien | Protien | n/a |