Symbol: Name: ID: |
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) GFS:2278 |
Gene name: | UBE2I |
Chromosome: | 16p13.3 |
Previous Symbols: | |
Previous Names: | ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9) |
Aliases: | UBC9 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107365 | Rat Genome Database ID: | RGD:3926 |
HGNC ID: | HGNC:12485 | RefSeq IDs: | NM_003345 |
Entrez Gene ID: | 7329 | Ensembl Gene ID: | ENSG00000103275 |
VEGA IDs: | OTTHUMG00000047845 | UniProt ID: | P63279 |
UCSC ID: | uc002clc.1 | OMIM ID: | 601661 |
Pubmed: | PMID8565643 | ||
CCDS IDs: | CCDSCCDS10433.1 |
SUMO-conjugating enzyme UBC9 is a protein that in humans is encoded by the UBE2I gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation.
Products for UBE2I gene
Catalog | Product Name | Application | Company |
GFS:E02278 | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ELISA kit | ELISA | n/a |
GFS:A02278 | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); Anti | ANTIBODIES | n/a |
GFS:P02278 | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); Protien | Protien | n/a |