Symbol: Name: ID: |
UBE2M ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) GFS:2285 |
Gene name: | UBE2M |
Chromosome: | 19q13.43 |
Previous Symbols: | |
Previous Names: | ubiquitin-conjugating enzyme E2M (homologous to yeast UBC12) |
Aliases: | hUbc12, UBC12 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108278 | Rat Genome Database ID: | RGD:1307614 |
HGNC ID: | HGNC:12491 | RefSeq IDs: | NM_003969 |
Entrez Gene ID: | 9040 | Ensembl Gene ID: | ENSG00000130725 |
VEGA IDs: | UniProt ID: | P61081 | |
UCSC ID: | uc002qtl.3 | OMIM ID: | 603173 |
Pubmed: | PMID9694792 | ||
CCDS IDs: | CCDSCCDS12987.1 |
NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Products for UBE2M gene
Catalog | Product Name | Application | Company |
GFS:E02285 | ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast); ELISA kit | ELISA | n/a |
GFS:A02285 | ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast); Anti | ANTIBODIES | n/a |
GFS:P02285 | ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast); Protien | Protien | n/a |