Symbol: Name: ID: |
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) GFS:2267 |
Gene name: | UBE2D1 |
Chromosome: | 10q21.1 |
Previous Symbols: | SFT |
Previous Names: | stimulator of Fe transport |
Aliases: | UbcH5A, UBCH5, UBC4/5, E2(17)KB1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2384911 | Rat Genome Database ID: | RGD:1307886 |
HGNC ID: | HGNC:12474 | RefSeq IDs: | NM_003338 |
Entrez Gene ID: | 7321 | Ensembl Gene ID: | ENSG00000072401 |
VEGA IDs: | OTTHUMG00000018269 | UniProt ID: | P51668 |
UCSC ID: | uc001jke.1 | OMIM ID: | 602961 |
Pubmed: | PMID10072594 PMID 8530467 | ||
CCDS IDs: | CCDSCCDS7252.1 |
Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of CHIP, TRAF6 and TRIM63/MURF1. Ubiquitinates CHIP-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
Products for UBE2D1 gene
Catalog | Product Name | Application | Company |
GFS:E02267 | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); ELISA kit | ELISA | n/a |
GFS:A02267 | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); Anti | ANTIBODIES | n/a |
GFS:P02267 | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); Protien | Protien | n/a |