Symbol: Name: ID: |
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) GFS:2268 |
Gene name: | UBE2D2 |
Chromosome: | 5q31.3 |
Previous Symbols: | |
Previous Names: | ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5) |
Aliases: | UbcH5B, UBC4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1930715 | Rat Genome Database ID: | RGD:1591897 |
HGNC ID: | HGNC:12475 | RefSeq IDs: | NM_003339 |
Entrez Gene ID: | 7322 | Ensembl Gene ID: | ENSG00000131508 |
VEGA IDs: | UniProt ID: | P62837 | |
UCSC ID: | uc003ler.2 | OMIM ID: | 602962 |
Pubmed: | PMID8530467 | ||
CCDS IDs: | CCDSCCDS43369.1 CCDS CCDS47275.1 |
Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the UBE2D2 gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq].
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of CHIP and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
Products for UBE2D2 gene
Catalog | Product Name | Application | Company |
GFS:E02268 | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); ELISA kit | ELISA | n/a |
GFS:A02268 | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); Anti | ANTIBODIES | n/a |
GFS:P02268 | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); Protien | Protien | n/a |