Symbol: Name: ID: |
UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog) GFS:2265 |
Gene name: | UBE2A |
Chromosome: | Xq24 |
Previous Symbols: | |
Previous Names: | |
Aliases: | UBC2, HHR6A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:102959 | Rat Genome Database ID: | RGD:1359534 |
HGNC ID: | HGNC:12472 | RefSeq IDs: | NM_003336 |
Entrez Gene ID: | 7319 | Ensembl Gene ID: | ENSG00000077721 |
VEGA IDs: | OTTHUMG00000022275 | UniProt ID: | P49459 |
UCSC ID: | uc004erl.2 | OMIM ID: | 312180 |
Pubmed: | PMID1559696 | ||
CCDS IDs: | CCDSCCDS14580.1 CCDS CCDS14581.1 CCDS CCDS14582.1 |
Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq].
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.
Products for UBE2A gene
Catalog | Product Name | Application | Company |
GFS:E02265 | ubiquitin-conjugating enzyme E2A (RAD6 homolog); ELISA kit | ELISA | n/a |
GFS:A02265 | ubiquitin-conjugating enzyme E2A (RAD6 homolog); Anti | ANTIBODIES | n/a |
GFS:P02265 | ubiquitin-conjugating enzyme E2A (RAD6 homolog); Protien | Protien | n/a |