Symbol: Name: ID: |
UBE2C ubiquitin-conjugating enzyme E2C GFS:5068 |
Gene name: | UBE2C |
Chromosome: | 20q13.12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | UBCH10 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1915862 | Rat Genome Database ID: | RGD:1305382 |
HGNC ID: | HGNC:15937 | RefSeq IDs: | NM_007019 |
Entrez Gene ID: | 11065 | Ensembl Gene ID: | ENSG00000175063 |
VEGA IDs: | OTTHUMG00000033038 | UniProt ID: | O00762 |
UCSC ID: | uc002xpm.2 | OMIM ID: | 605574 |
Pubmed: | PMID9122200 | ||
CCDS IDs: | CCDSCCDS13370.1 CCDS CCDS13371.1 CCDS CCDS13372.1 CCDS CCDS13373.1 CCDS CCDS13374.1 |
Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Products for UBE2C gene
Catalog | Product Name | Application | Company |
GFS:E05068 | ubiquitin-conjugating enzyme E2C; ELISA kit | ELISA | n/a |
GFS:A05068 | ubiquitin-conjugating enzyme E2C; Anti | ANTIBODIES | n/a |
GFS:P05068 | ubiquitin-conjugating enzyme E2C; Protien | Protien | n/a |