Symbol: Name: ID: |
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 GFS:2288 |
Gene name: | UBE2V2 |
Chromosome: | 8q11.21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | UEV-2, DDVit-1, EDPF-1, MMS2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917870 | Rat Genome Database ID: | RGD:727838 |
HGNC ID: | HGNC:12495 | RefSeq IDs: | NM_003350 |
Entrez Gene ID: | 7336 | Ensembl Gene ID: | ENSG00000169139 |
VEGA IDs: | UniProt ID: | Q15819 | |
UCSC ID: | uc003xqm.2 | OMIM ID: | 603001 |
Pubmed: | PMID9418904 PMID 9199207 | ||
CCDS IDs: | CCDSCCDS43738.1 |
Ubiquitin-conjugating enzyme E2 variant 2 is a protein that in humans is encoded by the UBE2V2 gene.
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Products for UBE2V2 gene
Catalog | Product Name | Application | Company |
GFS:E02288 | ubiquitin-conjugating enzyme E2 variant 2; ELISA kit | ELISA | n/a |
GFS:A02288 | ubiquitin-conjugating enzyme E2 variant 2; Anti | ANTIBODIES | n/a |
GFS:P02288 | ubiquitin-conjugating enzyme E2 variant 2; Protien | Protien | n/a |