Symbol: Name: ID: |
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 GFS:2287 |
Gene name: | UBE2V1 |
Chromosome: | 20q13.2 |
Previous Symbols: | UBE2V |
Previous Names: | |
Aliases: | UEV-1, CROC-1, UEV1A, CROC1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1913839 | Rat Genome Database ID: | RGD:1305503 |
HGNC ID: | HGNC:12494 | RefSeq IDs: | NM_001032288 |
Entrez Gene ID: | 7335 | Ensembl Gene ID: | ENSG00000244687 |
VEGA IDs: | OTTHUMG00000152626 | UniProt ID: | Q13404 |
UCSC ID: | OMIM ID: | 602995 | |
Pubmed: | PMID9418904 PMID 9305758 | ||
CCDS IDs: | CCDSCCDS13426.1 CCDS CCDS13427.1 CCDS CCDS33483.1 |
Ubiquitin-conjugating enzyme E2 variant 1 is a protein that in humans is encoded by the UBE2V1 gene.
Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Multiple alternatively spliced transcripts encoding different isoforms have been described for this gene. A pseudogene has been identified which is also located on chromosome 20. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. (provided by RefSeq) .
Function: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Products for UBE2V1 gene
Catalog | Product Name | Application | Company |
GFS:E02287 | ubiquitin-conjugating enzyme E2 variant 1; ELISA kit | ELISA | n/a |
GFS:A02287 | ubiquitin-conjugating enzyme E2 variant 1; Anti | ANTIBODIES | n/a |
GFS:P02287 | ubiquitin-conjugating enzyme E2 variant 1; Protien | Protien | n/a |