Symbol: Name: ID: |
SF3B3 splicing factor 3b, subunit 3, 130kDa GFS:689 |
Gene name: | SF3B3 |
Chromosome: | 16q22 |
Previous Symbols: | |
Previous Names: | splicing factor 3b, subunit 3, 130kD |
Aliases: | SAP130, SF3b130, RSE1, KIAA0017 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1289341 | Rat Genome Database ID: | RGD:1311636 |
HGNC ID: | HGNC:10770 | RefSeq IDs: | NM_012426 |
Entrez Gene ID: | 23450 | Ensembl Gene ID: | ENSG00000189091 |
VEGA IDs: | OTTHUMG00000137582 | UniProt ID: | Q15393 |
UCSC ID: | uc002ezf.2 | OMIM ID: | 605592 |
Pubmed: | PMID10490618 | ||
CCDS IDs: | CCDSCCDS10894.1 |
Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene. This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron
Products for SF3B3 gene
Catalog | Product Name | Application | Company |
GFS:E00689 | splicing factor 3b, subunit 3, 130kDa; ELISA kit | ELISA | n/a |
GFS:A00689 | splicing factor 3b, subunit 3, 130kDa; Anti | ANTIBODIES | n/a |
GFS:P00689 | splicing factor 3b, subunit 3, 130kDa; Protien | Protien | n/a |