Symbol: Name: ID: |
SRSF2 serine/arginine-rich splicing factor 2 GFS:702 |
Gene name: | SRSF2 |
Chromosome: | 17q25.2 |
Previous Symbols: | SFRS2 |
Previous Names: | splicing factor, arginine/serine-rich 2 |
Aliases: | SC-35, SC35, PR264, SFRS2A |
Name Aliases: | SR splicing factor 2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98284 | Rat Genome Database ID: | RGD:1359422 |
HGNC ID: | HGNC:10783 | RefSeq IDs: | NM_001195427 |
Entrez Gene ID: | 6427 | Ensembl Gene ID: | ENSG00000161547 |
VEGA IDs: | UniProt ID: | Q01130 | |
UCSC ID: | uc002jsv.2 | OMIM ID: | 600813 |
Pubmed: | PMID8530103 PMID 20516191 | ||
CCDS IDs: | CCDSCCDS11749.1 |
Splicing factor, arginine/serine-rich 2 is a protein that in humans is encoded by the SFRS2 gene. The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq].
Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway
Products for SRSF2 gene
Catalog | Product Name | Application | Company |
GFS:E00702 | serine/arginine-rich splicing factor 2; ELISA kit | ELISA | n/a |
GFS:A00702 | serine/arginine-rich splicing factor 2; Anti | ANTIBODIES | n/a |
GFS:P00702 | serine/arginine-rich splicing factor 2; Protien | Protien | n/a |