Symbol: Name: ID: |
SRSF1 serine/arginine-rich splicing factor 1 GFS:699 |
Gene name: | SRSF1 |
Chromosome: | 17q22 |
Previous Symbols: | SFRS1 |
Previous Names: | splicing factor, arginine/serine-rich 1 |
Aliases: | ASF, SF2, SRp30a, SF2p33, MGC5228 |
Name Aliases: | splicing factor 2, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98283 | Rat Genome Database ID: | RGD:1587490 |
HGNC ID: | HGNC:10780 | RefSeq IDs: | NM_001078166 |
Entrez Gene ID: | 6426 | Ensembl Gene ID: | ENSG00000136450 |
VEGA IDs: | UniProt ID: | Q07955 | |
UCSC ID: | uc002ivi.2 | OMIM ID: | 600812 |
Pubmed: | PMID8530103 PMID 20516191 | ||
CCDS IDs: | CCDSCCDS11600.1 |
ASF/SF2 (alternative splicing factor/splicing factor 2) also known as splicing factor, arginine/serine-rich 1 or SFRS1, is a protein which in humans is encoded by the SFRS1 gene. This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13. [provided by RefSeq].
Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors
Products for SRSF1 gene
Catalog | Product Name | Application | Company |
GFS:E00699 | serine/arginine-rich splicing factor 1; ELISA kit | ELISA | n/a |
GFS:A00699 | serine/arginine-rich splicing factor 1; Anti | ANTIBODIES | n/a |
GFS:P00699 | serine/arginine-rich splicing factor 1; Protien | Protien | n/a |