Symbol: Name: ID: |
SFRP1 secreted frizzled-related protein 1 GFS:694 |
Gene name: | SFRP1 |
Chromosome: | 8p11.21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SARP2, FRP, FRP-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:892014 | Rat Genome Database ID: | RGD:621074 |
HGNC ID: | HGNC:10776 | RefSeq IDs: | NM_003012 |
Entrez Gene ID: | 6422 | Ensembl Gene ID: | ENSG00000104332 |
VEGA IDs: | UniProt ID: | Q8N474 | |
UCSC ID: | uc003xnt.2 | OMIM ID: | 604156 |
Pubmed: | PMID9391078 PMID 9192640 | ||
CCDS IDs: | CCDSCCDS34886.1 |
Secreted frizzled-related protein 1 also known as SFRP1 is a protein which in humans is encoded by the SFRP1 gene. This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
Products for SFRP1 gene
Catalog | Product Name | Application | Company |
GFS:E00694 | secreted frizzled-related protein 1; ELISA kit | ELISA | n/a |
GFS:A00694 | secreted frizzled-related protein 1; Anti | ANTIBODIES | n/a |
GFS:P00694 | secreted frizzled-related protein 1; Protien | Protien | n/a |