Symbol: Name: ID: |
SF3A1 splicing factor 3a, subunit 1, 120kDa GFS:683 |
Gene name: | SF3A1 |
Chromosome: | 22q12.2 |
Previous Symbols: | |
Previous Names: | splicing factor 3a, subunit 1, 120kD |
Aliases: | SF3a120, SAP114, PRPF21, Prp21 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914715 | Rat Genome Database ID: | RGD:1311477 |
HGNC ID: | HGNC:10765 | RefSeq IDs: | NM_001005409 |
Entrez Gene ID: | 10291 | Ensembl Gene ID: | ENSG00000099995 |
VEGA IDs: | OTTHUMG00000151005 | UniProt ID: | Q15459 |
UCSC ID: | uc003ahl.2 | OMIM ID: | 605595 |
Pubmed: | PMID7489498 | ||
CCDS IDs: | CCDSCCDS13875.1 CCDS CCDS46684.1 |
Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene. This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex
Products for SF3A1 gene
Catalog | Product Name | Application | Company |
GFS:E00683 | splicing factor 3a, subunit 1, 120kDa; ELISA kit | ELISA | n/a |
GFS:A00683 | splicing factor 3a, subunit 1, 120kDa; Anti | ANTIBODIES | n/a |
GFS:P00683 | splicing factor 3a, subunit 1, 120kDa; Protien | Protien | n/a |