Symbol: Name: ID: |
SF3B2 splicing factor 3b, subunit 2, 145kDa GFS:687 |
Gene name: | SF3B2 |
Chromosome: | 11q13 |
Previous Symbols: | |
Previous Names: | splicing factor 3b, subunit 2, 145kD |
Aliases: | SAP145, SF3b1, Cus1, SF3b145 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2441856 | Rat Genome Database ID: | RGD:1307159 |
HGNC ID: | HGNC:10769 | RefSeq IDs: | NM_006842 |
Entrez Gene ID: | 10992 | Ensembl Gene ID: | ENSG00000087365 |
VEGA IDs: | UniProt ID: | Q13435 | |
UCSC ID: | uc001ogy.1 | OMIM ID: | 605591 |
Pubmed: | PMID8566756 | ||
CCDS IDs: | CCDSCCDS31612.1 |
Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene. This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron
Products for SF3B2 gene
Catalog | Product Name | Application | Company |
GFS:E00687 | splicing factor 3b, subunit 2, 145kDa; ELISA kit | ELISA | n/a |
GFS:A00687 | splicing factor 3b, subunit 2, 145kDa; Anti | ANTIBODIES | n/a |
GFS:P00687 | splicing factor 3b, subunit 2, 145kDa; Protien | Protien | n/a |