Symbol: Name: ID: |
SF3B1 splicing factor 3b, subunit 1, 155kDa GFS:686 |
Gene name: | SF3B1 |
Chromosome: | 2q33.1 |
Previous Symbols: | |
Previous Names: | splicing factor 3b, subunit 1, 155kD |
Aliases: | SAP155, SF3b155, PRPF10, Prp10, Hsh155 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1932339 | Rat Genome Database ID: | RGD:620148 |
HGNC ID: | HGNC:10768 | RefSeq IDs: | NM_001005526 |
Entrez Gene ID: | 23451 | Ensembl Gene ID: | ENSG00000115524 |
VEGA IDs: | OTTHUMG00000154447 | UniProt ID: | O75533 |
UCSC ID: | uc002uue.2 | OMIM ID: | 605590 |
Pubmed: | PMID9585501 | ||
CCDS IDs: | CCDSCCDS33356.1 CCDS CCDS46479.1 |
Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 geneThis gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron
Products for SF3B1 gene
Catalog | Product Name | Application | Company |
GFS:E00686 | splicing factor 3b, subunit 1, 155kDa; ELISA kit | ELISA | n/a |
GFS:A00686 | splicing factor 3b, subunit 1, 155kDa; Anti | ANTIBODIES | n/a |
GFS:P00686 | splicing factor 3b, subunit 1, 155kDa; Protien | Protien | n/a |