Symbol: Name: ID: |
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa GFS:1391 |
Gene name: | TAF1C |
Chromosome: | 16q24 |
Previous Symbols: | |
Previous Names: | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD |
Aliases: | TAFI110, TAFI95, SL1, MGC:39976 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109576 | Rat Genome Database ID: | RGD:1305658 |
HGNC ID: | HGNC:11534 | RefSeq IDs: | NM_005679 |
Entrez Gene ID: | 9013 | Ensembl Gene ID: | ENSG00000103168 |
VEGA IDs: | UniProt ID: | Q15572 | |
UCSC ID: | uc002fhm.2 | OMIM ID: | 604905 |
Pubmed: | PMID7801123 | ||
CCDS IDs: | CCDSCCDS32496.1 CCDS CCDS45535.1 |
TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene. Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified. (provided by RefSeq)
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC(preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.
Products for TAF1C gene
Catalog | Product Name | Application | Company |
GFS:E01391 | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa; ELISA kit | ELISA | n/a |
GFS:A01391 | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa; Anti | ANTIBODIES | n/a |
GFS:P01391 | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa; Protien | Protien | n/a |