Symbol: Name: ID: |
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa GFS:1390 |
Gene name: | TAF1B |
Chromosome: | 2p25 |
Previous Symbols: | |
Previous Names: | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kD |
Aliases: | TAFI63, SL1, RAF1B, RAFI63 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109577 | Rat Genome Database ID: | RGD:1596058 |
HGNC ID: | HGNC:11533 | RefSeq IDs: | NM_005680 |
Entrez Gene ID: | 9014 | Ensembl Gene ID: | ENSG00000115750 |
VEGA IDs: | OTTHUMG00000151673 | UniProt ID: | Q53T94 |
UCSC ID: | uc002qzz.2 | OMIM ID: | 604904 |
Pubmed: | PMID7801123 | ||
CCDS IDs: | CCDSCCDS33143.1 |
TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene. Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. (provided by RefSeq)
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
Products for TAF1B gene
Catalog | Product Name | Application | Company |
GFS:E01390 | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa; ELISA kit | ELISA | n/a |
GFS:A01390 | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa; Anti | ANTIBODIES | n/a |
GFS:P01390 | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa; Protien | Protien | n/a |