Symbol: Name: ID: |
LITAF lipopolysaccharide-induced TNF factor GFS:5928 |
Gene name: | LITAF |
Chromosome: | 16p13.3-p12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | PIG7, SIMPLE, FLJ38636, TP53I7 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929512 | Rat Genome Database ID: | RGD:69294 |
HGNC ID: | HGNC:16841 | RefSeq IDs: | NM_001136472 |
Entrez Gene ID: | 9516 | Ensembl Gene ID: | ENSG00000189067 |
VEGA IDs: | UniProt ID: | Q99732 | |
UCSC ID: | uc002dbb.2 | OMIM ID: | 603795 |
Pubmed: | PMID9305847 PMID 10200294 | ||
CCDS IDs: | CCDSCCDS32386.1 CCDS CCDS45411.1 |
Lipopolysaccharide-induced tumor necrosis factor-alpha factor is a protein that in humans is encoded by the LITAF gene.
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2008].
Function: Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.
Products for LITAF gene
Catalog | Product Name | Application | Company |
GFS:E05928 | lipopolysaccharide-induced TNF factor; ELISA kit | ELISA | n/a |
GFS:A05928 | lipopolysaccharide-induced TNF factor; Anti | ANTIBODIES | n/a |
GFS:P05928 | lipopolysaccharide-induced TNF factor; Protien | Protien | n/a |