Symbol: Name: ID: |
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa GFS:1394 |
Gene name: | TAF4 |
Chromosome: | 20q13.33 |
Previous Symbols: | TAF4A, TAF2C1, TAF2C |
Previous Names: | TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD |
Aliases: | TAFII130, TAFII135 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2152346 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11537 | RefSeq IDs: | NM_003185 |
Entrez Gene ID: | 6874 | Ensembl Gene ID: | ENSG00000130699 |
VEGA IDs: | OTTHUMG00000032893 | UniProt ID: | O00268 |
UCSC ID: | uc002ybs.2 | OMIM ID: | 601796 |
Pubmed: | PMID8942982 PMID 9192867 | ||
CCDS IDs: | CCDSCCDS33500.1 |
Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. (provided by RefSeq)
Makes part of TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.
Products for TAF4 gene
Catalog | Product Name | Application | Company |
GFS:E01394 | TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa; ELISA kit | ELISA | n/a |
GFS:A01394 | TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa; Anti | ANTIBODIES | n/a |
GFS:P01394 | TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa; Protien | Protien | n/a |