Symbol: Name: ID: |
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa GFS:1399 |
Gene name: | TAF9 |
Chromosome: | 5q11.2-q13.1 |
Previous Symbols: | TAF2G |
Previous Names: | TATA box binding protein (TBP)-associated factor, RNA polymerase II, G, 32kD |
Aliases: | TAFII31, TAFII32, TAFIID32, MGC5067, CGI-137, MGC1603, MGC3647, CINAP, AD-004, AK6 |
Name Aliases: | coilin interacting protein, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1888697 | Rat Genome Database ID: | RGD:727861 |
HGNC ID: | HGNC:11542 | RefSeq IDs: | NM_001015891 |
Entrez Gene ID: | 6880 | Ensembl Gene ID: | ENSG00000085231 |
VEGA IDs: | OTTHUMG00000099359 | UniProt ID: | Q16594 |
UCSC ID: | uc003jwa.2 | OMIM ID: | 600822 |
Pubmed: | PMID10191103 PMID 15630091 | ||
CCDS IDs: | CCDSCCDS4001.1 CCDS CCDS4002.1 CCDS CCDS43324.1 |
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein which in humans is encoded by the TAF9 gene. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq) .
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.
Products for TAF9 gene
Catalog | Product Name | Application | Company |
GFS:E01399 | TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa; ELISA kit | ELISA | n/a |
GFS:A01399 | TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa; Anti | ANTIBODIES | n/a |
GFS:P01399 | TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa; Protien | Protien | n/a |