Symbol: Name: ID: |
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa GFS:1404 |
Gene name: | TAF15 |
Chromosome: | 17q11.1-q11.2 |
Previous Symbols: | TAF2N |
Previous Names: | TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56) |
Aliases: | hTAFII68, RBP56, Npl3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917689 | Rat Genome Database ID: | RGD:1309595 |
HGNC ID: | HGNC:11547 | RefSeq IDs: | NM_003487 |
Entrez Gene ID: | 8148 | Ensembl Gene ID: | ENSG00000172660 |
VEGA IDs: | UniProt ID: | Q92804 | |
UCSC ID: | uc002hkd.2 | OMIM ID: | 601574 |
Pubmed: | PMID8954779 PMID 9795213 | ||
CCDS IDs: | CCDSCCDS32623.1 |
TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified. [provided by RefSeq].
RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).
Products for TAF15 gene
Catalog | Product Name | Application | Company |
GFS:E01404 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; ELISA kit | ELISA | n/a |
GFS:A01404 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; Anti | ANTIBODIES | n/a |
GFS:P01404 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; Protien | Protien | n/a |