Symbol: Name: ID: |
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa GFS:6386 |
Gene name: | TAF8 |
Chromosome: | 6p21.1 |
Previous Symbols: | TBN |
Previous Names: | TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa, "taube nuss homolog (mouse)" |
Aliases: | FLJ32821, TAF(II)43 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1926879 | Rat Genome Database ID: | RGD:1308423 |
HGNC ID: | HGNC:17300 | RefSeq IDs: | NM_138572 |
Entrez Gene ID: | 129685 | Ensembl Gene ID: | ENSG00000137413 |
VEGA IDs: | OTTHUMG00000014692 | UniProt ID: | Q7Z7C8 |
UCSC ID: | uc003ors.2 | OMIM ID: | 609514 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS43462.1 |
Transcription initiation factor TFIID subunit 8 is a protein that in humans is encoded by the TAF8 gene.
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Function: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).
Products for TAF8 gene
Catalog | Product Name | Application | Company |
GFS:E06386 | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa; ELISA kit | ELISA | n/a |
GFS:A06386 | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa; Anti | ANTIBODIES | n/a |
GFS:P06386 | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa; Protien | Protien | n/a |