Symbol: Name: ID: |
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa GFS:1392 |
Gene name: | TAF1 |
Chromosome: | Xq13.1 |
Previous Symbols: | TAF2A, BA2R, CCG1, CCGS, DYT3 |
Previous Names: | TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 250kD, "dystonia 3 (with Parkinsonism)" |
Aliases: | NSCL2, TAFII250, KAT4, DYT3/TAF1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1336878 | Rat Genome Database ID: | RGD:1562050 |
HGNC ID: | HGNC:11535 | RefSeq IDs: | NM_004606 |
Entrez Gene ID: | 6872 | Ensembl Gene ID: | ENSG00000147133 |
VEGA IDs: | OTTHUMG00000022723 | UniProt ID: | P21675 |
UCSC ID: | uc004dzt.3 | OMIM ID: | 313650 |
Pubmed: | PMID3556424 PMID 12928496 PMID 17952504 | ||
CCDS IDs: | CCDSCCDS14412.1 CCDS CCDS35325.1 |
Transcription initiation factor TFIID subunit 1, also known as transcription initiation factor TFIID 250 kDa subunit (TAFII-250) or TBP-associated factor 250 kDa (p250), is a protein that in humans is encoded by the TAF1 gene. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.(provided by RefSeq) .
Products for TAF1 gene
Catalog | Product Name | Application | Company |
GFS:E01392 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; ELISA kit | ELISA | n/a |
GFS:A01392 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; Anti | ANTIBODIES | n/a |
GFS:P01392 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; Protien | Protien | n/a |