Symbol: Name: ID: |
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa GFS:1400 |
Gene name: | TAF10 |
Chromosome: | 11p15.5-p15.2 |
Previous Symbols: | TAF2H, TAF2A |
Previous Names: | TATA box binding protein (TBP)-associated factor, RNA polymerase II, H, 30kD |
Aliases: | TAFII30 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1346320 | Rat Genome Database ID: | RGD:1305907 |
HGNC ID: | HGNC:11543 | RefSeq IDs: | NM_006284 |
Entrez Gene ID: | 6881 | Ensembl Gene ID: | ENSG00000166337 |
VEGA IDs: | OTTHUMG00000133402 | UniProt ID: | Q12962 |
UCSC ID: | uc001mej.1 | OMIM ID: | 600475 |
Pubmed: | PMID7923369 | ||
CCDS IDs: | CCDSCCDS7769.1 |
Transcription initiation factor TFIID subunit 10 is a protein that in humans is encoded by the TAF10 gene. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. (provided by RefSeq) .
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
Products for TAF10 gene
Catalog | Product Name | Application | Company |
GFS:E01400 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa; ELISA kit | ELISA | n/a |
GFS:A01400 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa; Anti | ANTIBODIES | n/a |
GFS:P01400 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa; Protien | Protien | n/a |