Symbol: Name: ID: |
CDK8 cyclin-dependent kinase 8 GFS:6694 |
Gene name: | CDK8 |
Chromosome: | 13q12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | K35 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1196224 | Rat Genome Database ID: | |
HGNC ID: | HGNC:1779 | RefSeq IDs: | NM_001260 |
Entrez Gene ID: | 1024 | Ensembl Gene ID: | ENSG00000132964 |
VEGA IDs: | OTTHUMG00000016617 | UniProt ID: | P49336 |
UCSC ID: | uc001uqr.1 | OMIM ID: | 603184 |
Pubmed: | PMID7568034 | ||
CCDS IDs: | CCDSCCDS9317.1 |
Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene.
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
Products for CDK8 gene
Catalog | Product Name | Application | Company |
GFS:E06694 | cyclin-dependent kinase 8; ELISA kit | ELISA | n/a |
GFS:A06694 | cyclin-dependent kinase 8; Anti | ANTIBODIES | n/a |
GFS:P06694 | cyclin-dependent kinase 8; Protien | Protien | n/a |