Symbol: Name: ID: |
CDK4 cyclin-dependent kinase 4 GFS:6653 |
Gene name: | CDK4 |
Chromosome: | 12q13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | PSK-J3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88357 | Rat Genome Database ID: | RGD:621120 |
HGNC ID: | HGNC:1773 | RefSeq IDs: | NM_000075 |
Entrez Gene ID: | 1019 | Ensembl Gene ID: | ENSG00000135446 |
VEGA IDs: | UniProt ID: | P11802 | |
UCSC ID: | uc001spv.2 | OMIM ID: | 123829 |
Pubmed: | PMID8275715 | ||
CCDS IDs: | CCDSCCDS8953.1 |
Cyclin-dependent kinase 4 is part of the cyclin-dependent kinase family.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex
Products for CDK4 gene
Catalog | Product Name | Application | Company |
GFS:E06653 | cyclin-dependent kinase 4; ELISA kit | ELISA | n/a |
GFS:A06653 | cyclin-dependent kinase 4; Anti | ANTIBODIES | n/a |
GFS:P06653 | cyclin-dependent kinase 4; Protien | Protien | n/a |