Symbol: Name: ID: |
CDK11A cyclin-dependent kinase 11A GFS:6385 |
Gene name: | CDK11A |
Chromosome: | 1p36.33 |
Previous Symbols: | CDC2L3, CDC2L2 |
Previous Names: | cell division cycle 2-like 2, "cell division cycle 2-like 2 (PITSLRE proteins)" |
Aliases: | PITSLRE, CDK11-p110, CDK11-p58, CDK11-p46, p58GTA |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:1730 | RefSeq IDs: | XM_002346361 |
Entrez Gene ID: | 728642 | Ensembl Gene ID: | ENSG00000008128 |
VEGA IDs: | OTTHUMG00000000703 | UniProt ID: | Q9UQ88 |
UCSC ID: | OMIM ID: | 116951 | |
Pubmed: | PMID7920654 PMID 9750192 PMID 19884882 | ||
CCDS IDs: | CCDSCCDS44042.1 CCDS CCDS44043.1 |
PITSLRE serine/threonine-protein kinase CDC2L2 is an enzyme that in humans is encoded by the CDC2L2 gene.
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. (provided by RefSeq)
Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
Products for CDK11A gene
Catalog | Product Name | Application | Company |
GFS:E06385 | cyclin-dependent kinase 11A; ELISA kit | ELISA | n/a |
GFS:A06385 | cyclin-dependent kinase 11A; Anti | ANTIBODIES | n/a |
GFS:P06385 | cyclin-dependent kinase 11A; Protien | Protien | n/a |