Symbol: Name: ID: |
CDK1 cyclin-dependent kinase 1 GFS:6306 |
Gene name: | CDK1 |
Chromosome: | 10q21.2 |
Previous Symbols: | CDC2 |
Previous Names: | cell division cycle 2, G1 to S and G2 to M |
Aliases: | CDC28A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88351 | Rat Genome Database ID: | RGD:2319 |
HGNC ID: | HGNC:1722 | RefSeq IDs: | NM_001170406 |
Entrez Gene ID: | 983 | Ensembl Gene ID: | ENSG00000170312 |
VEGA IDs: | OTTHUMG00000018290 | UniProt ID: | P06493 |
UCSC ID: | uc001jld.2 | OMIM ID: | 116940 |
Pubmed: | PMID3553962 PMID 19884882 | ||
CCDS IDs: | CCDSCCDS7260.1 CCDS CCDS44408.1 |
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
Function: Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
Products for CDK1 gene
Catalog | Product Name | Application | Company |
GFS:E06306 | cyclin-dependent kinase 1; ELISA kit | ELISA | n/a |
GFS:A06306 | cyclin-dependent kinase 1; Anti | ANTIBODIES | n/a |
GFS:P06306 | cyclin-dependent kinase 1; Protien | Protien | n/a |