Symbol: Name: ID: |
CDK11B cyclin-dependent kinase 11B GFS:6373 |
Gene name: | CDK11B |
Chromosome: | 1p36.33 |
Previous Symbols: | CDC2L1 |
Previous Names: | cell division cycle 2-like 1 (PITSLRE proteins) |
Aliases: | CDK11-p110, CDK11-p58, CDK11-p46 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88353 | Rat Genome Database ID: | RGD:628604 |
HGNC ID: | HGNC:1729 | RefSeq IDs: | XM_001714086 |
Entrez Gene ID: | 984 | Ensembl Gene ID: | |
VEGA IDs: | UniProt ID: | P21127 | |
UCSC ID: | uc001agv.1 | OMIM ID: | 176873 |
Pubmed: | PMID1774066 PMID 14511641 PMID 19884882 | ||
CCDS IDs: |
PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDC2L1 gene.
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq, Jul 2008].
Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
Products for CDK11B gene
Catalog | Product Name | Application | Company |
GFS:E06373 | cyclin-dependent kinase 11B; ELISA kit | ELISA | n/a |
GFS:A06373 | cyclin-dependent kinase 11B; Anti | ANTIBODIES | n/a |
GFS:P06373 | cyclin-dependent kinase 11B; Protien | Protien | n/a |