Symbol: Name: ID: |
CDK13 cyclin-dependent kinase 13 GFS:6410 |
Gene name: | CDK13 |
Chromosome: | 7p14.1 |
Previous Symbols: | CDC2L5 |
Previous Names: | cell division cycle 2-like 5 (cholinesterase-related cell division controller) |
Aliases: | CHED, CDC2L, KIAA1791 |
Name Aliases: | cholinesterase-related cell division controller |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916812 | Rat Genome Database ID: | RGD:1311226 |
HGNC ID: | HGNC:1733 | RefSeq IDs: | NM_003718 |
Entrez Gene ID: | 8621 | Ensembl Gene ID: | ENSG00000065883 |
VEGA IDs: | OTTHUMG00000023726 | UniProt ID: | Q14004 |
UCSC ID: | uc003thh.3 | OMIM ID: | 603309 |
Pubmed: | PMID1731328 PMID 19884882 | ||
CCDS IDs: | CCDSCCDS5461.1 CCDS CCDS5462.1 |
Cell division cycle 2-like protein kinase 5 is an enzyme that in humans is encoded by the CDC2L5 gene.
The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009].
Function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
Products for CDK13 gene
Catalog | Product Name | Application | Company |
GFS:E06410 | cyclin-dependent kinase 13; ELISA kit | ELISA | n/a |
GFS:A06410 | cyclin-dependent kinase 13; Anti | ANTIBODIES | n/a |
GFS:P06410 | cyclin-dependent kinase 13; Protien | Protien | n/a |