Symbol: Name: ID: |
CDK6 cyclin-dependent kinase 6 GFS:6681 |
Gene name: | CDK6 |
Chromosome: | 7q21-q22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | PLSTIRE |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1277162 | Rat Genome Database ID: | RGD:621121 |
HGNC ID: | HGNC:1777 | RefSeq IDs: | NM_001145306 |
Entrez Gene ID: | 1021 | Ensembl Gene ID: | ENSG00000105810 |
VEGA IDs: | OTTHUMG00000131697 | UniProt ID: | Q00534 |
UCSC ID: | uc010lez.2 | OMIM ID: | 603368 |
Pubmed: | PMID1639063 | ||
CCDS IDs: | CCDSCCDS5628.1 |
Cell division protein kinase 6 is an enzyme that in humans is encoded by the CDK6 gene.
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009].
Function: Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins.
Products for CDK6 gene
Catalog | Product Name | Application | Company |
GFS:E06681 | cyclin-dependent kinase 6; ELISA kit | ELISA | n/a |
GFS:A06681 | cyclin-dependent kinase 6; Anti | ANTIBODIES | n/a |
GFS:P06681 | cyclin-dependent kinase 6; Protien | Protien | n/a |