Symbol: Name: ID: |
FBXO8 F-box protein 8 GFS:3130 |
Gene name: | FBXO8 |
Chromosome: | 4q34.1 |
Previous Symbols: | |
Previous Names: | F-box only protein 8 |
Aliases: | FBX8, FBS |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1354696 | Rat Genome Database ID: | RGD:1307596 |
HGNC ID: | HGNC:13587 | RefSeq IDs: | NM_012180 |
Entrez Gene ID: | 26269 | Ensembl Gene ID: | ENSG00000164117 |
VEGA IDs: | UniProt ID: | Q9NRD0 | |
UCSC ID: | uc003itp.2 | OMIM ID: | 605649 |
Pubmed: | PMID10531035 PMID 10531037 | ||
CCDS IDs: | CCDSCCDS3820.1 |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008].
Function: May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential)
Products for FBXO8 gene
Catalog | Product Name | Application | Company |
GFS:E03130 | F-box protein 8; ELISA kit | ELISA | n/a |
GFS:A03130 | F-box protein 8; Anti | ANTIBODIES | n/a |
GFS:P03130 | F-box protein 8; Protien | Protien | n/a |