Symbol: Name: ID: |
FBXO22 F-box protein 22 GFS:3136 |
Gene name: | FBXO22 |
Chromosome: | 15q23 |
Previous Symbols: | |
Previous Names: | F-box only protein 22 |
Aliases: | FBX22, FISTC1 |
Name Aliases: | FIST domain containing 1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1926014 | Rat Genome Database ID: | RGD:1306664 |
HGNC ID: | HGNC:13593 | RefSeq IDs: | NM_012170 |
Entrez Gene ID: | 26263 | Ensembl Gene ID: | ENSG00000167196 |
VEGA IDs: | OTTHUMG00000142841 | UniProt ID: | Q8NEZ5 |
UCSC ID: | uc002bbk.2 | OMIM ID: | 609096 |
Pubmed: | PMID10531035 PMID 10531037 PMID 17855421 | ||
CCDS IDs: | CCDSCCDS10287.1 CCDS CCDS45310.1 |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity).
Products for FBXO22 gene
Catalog | Product Name | Application | Company |
GFS:E03136 | F-box protein 22; ELISA kit | ELISA | n/a |
GFS:A03136 | F-box protein 22; Anti | ANTIBODIES | n/a |
GFS:P03136 | F-box protein 22; Protien | Protien | n/a |