| Symbol: Name: ID: |
FBXO31 F-box protein 31 GFS:5618 |
| Gene name: | FBXO31 |
| Chromosome: | 16q24 |
| Previous Symbols: | |
| Previous Names: | F-box only protein 31 |
| Aliases: | FBX14, FBXO14, Fbx31, MGC15419 |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1354708 | Rat Genome Database ID: | RGD:1561069 |
| HGNC ID: | HGNC:16510 | RefSeq IDs: | NM_024735 |
| Entrez Gene ID: | 79791 | Ensembl Gene ID: | ENSG00000103264 |
| VEGA IDs: | UniProt ID: | Q5XUX0 | |
| UCSC ID: | uc002fju.2 | OMIM ID: | 609102 |
| Pubmed: | |||
| CCDS IDs: | CCDSCCDS32501.1 | ||
F-box only protein 31 is a protein that in humans is encoded by the FBXO31 gene.
Members of the F-box protein family, such as FBXO31, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM)
Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
Products for FBXO31 gene
| Catalog | Product Name | Application | Company |
| GFS:E05618 | F-box protein 31; ELISA kit | ELISA | n/a |
| GFS:A05618 | F-box protein 31; Anti | ANTIBODIES | n/a |
| GFS:P05618 | F-box protein 31; Protien | Protien | n/a |
