Symbol: Name: ID: |
FBXO18 F-box protein, helicase, 18 GFS:3162 |
Gene name: | FBXO18 |
Chromosome: | 10p15.1 |
Previous Symbols: | |
Previous Names: | F-box only protein 18 |
Aliases: | FBH1, FLJ14590, Fbx18 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1354699 | Rat Genome Database ID: | |
HGNC ID: | HGNC:13620 | RefSeq IDs: | NM_032807 |
Entrez Gene ID: | 84893 | Ensembl Gene ID: | ENSG00000134452 |
VEGA IDs: | OTTHUMG00000017609 | UniProt ID: | Q8NFZ0 |
UCSC ID: | uc001iit.2 | OMIM ID: | 607222 |
Pubmed: | PMID10531037 PMID 11956208 | ||
CCDS IDs: | CCDSCCDS7072.1 CCDS CCDS7073.1 |
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Function: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction.
Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination anddegradation.
Products for FBXO18 gene
Catalog | Product Name | Application | Company |
GFS:E03162 | F-box protein, helicase, 18; ELISA kit | ELISA | n/a |
GFS:A03162 | F-box protein, helicase, 18; Anti | ANTIBODIES | n/a |
GFS:P03162 | F-box protein, helicase, 18; Protien | Protien | n/a |