Symbol: Name: ID: |
FBXO5 F-box protein 5 GFS:3127 |
Gene name: | FBXO5 |
Chromosome: | 6q25-q26 |
Previous Symbols: | |
Previous Names: | F-box only protein 5 |
Aliases: | FBX5, Fbxo31, EMI1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914391 | Rat Genome Database ID: | RGD:1309405 |
HGNC ID: | HGNC:13584 | RefSeq IDs: | NM_001142522 |
Entrez Gene ID: | 26271 | Ensembl Gene ID: | ENSG00000112029 |
VEGA IDs: | OTTHUMG00000015854 | UniProt ID: | Q9UKT4 |
UCSC ID: | uc003qpg.2 | OMIM ID: | 606013 |
Pubmed: | PMID10531035 PMID 10531037 | ||
CCDS IDs: | CCDSCCDS5242.1 CCDS CCDS47501.1 |
F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008].
Function: Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding.
Products for FBXO5 gene
Catalog | Product Name | Application | Company |
GFS:E03127 | F-box protein 5; ELISA kit | ELISA | n/a |
GFS:A03127 | F-box protein 5; Anti | ANTIBODIES | n/a |
GFS:P03127 | F-box protein 5; Protien | Protien | n/a |