Symbol: Name: ID: |
FBXO32 F-box protein 32 GFS:5823 |
Gene name: | FBXO32 |
Chromosome: | 8q24.13 |
Previous Symbols: | |
Previous Names: | F-box only protein 32 |
Aliases: | MAFbx, ATROGIN1, Fbx32 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914981 | Rat Genome Database ID: | RGD:620373 |
HGNC ID: | HGNC:16731 | RefSeq IDs: | NM_058229 |
Entrez Gene ID: | 114907 | Ensembl Gene ID: | ENSG00000156804 |
VEGA IDs: | UniProt ID: | Q969P5 | |
UCSC ID: | uc003yqr.2 | OMIM ID: | 606604 |
Pubmed: | PMID11679633 PMID 11717410 | ||
CCDS IDs: | CCDSCCDS6345.1 |
F-box only protein 32 is a protein that in humans is encoded by the FBXO32 gene.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].
Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
Products for FBXO32 gene
Catalog | Product Name | Application | Company |
GFS:E05823 | F-box protein 32; ELISA kit | ELISA | n/a |
GFS:A05823 | F-box protein 32; Anti | ANTIBODIES | n/a |
GFS:P05823 | F-box protein 32; Protien | Protien | n/a |